A Mapping of the Distribution of Lactic Dehydrogenase in the Brain of the Rhesus Monkey.

This article provides a quantitative mapping of the distribution of lactic dehydrogenase (LDH) activity in the nuclei and regions of the brain of the rhesus monkey. It represents one part of a program of systematic mappings of the distribution of various enzymes in the brain. Previous publications described the distribution of succinic dehydrogenase (SD) in guinea pig brain (Friede, '59 a, b; '60 a, b), four oxidative enzymes and capillarization in a cat brain brain stem atlas (Friede, '61 a) , and DPN-diaphorase in human brain (Friede and Fleming, '62). These studies were deliberately confined to enzymes involved in different phases of oxidative breakdown of glucose. A comparison of the data shows similar distribution of these enzymes in most of the regions of the brain; however, some exceptional nuclei showed definite differences in gross distribution. In addition, some finer differences in cytological distribution were found throughout the brain. Therefore, the present study emphasizes the comparison and the differences of patterns of LDH and SD with extensive reference made to the articles quoted above.